Gene: HAL
Alternate names for this Gene: HIS|HSTD
Gene Summary: Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene.
Gene is located in Chromosome: 12
Location in Chromosome : 12q23.1
Description of this Gene: histidine ammonia-lyase
Type of Gene: protein-coding
Gene: LOC102723340
Alternate names for this Gene:
Gene Summary:
Gene is located in Chromosome:
Location in Chromosome :
Description of this Gene:
Type of Gene:
rs76945459 in
HAL;LOC102723340 gene and
Increased histidine
PMID 15173056 2004 Inflammation as a cardiovascular risk factor.
PMID 25575548 2015 Association of Rare Loss-Of-Function Alleles in HAL, Serum Histidine: Levels and Incident Coronary Heart Disease.
PMID 23361591 2013 Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial.