Gene: HCK

Alternate names for this Gene: JTK9|p59Hck|p61Hck

Gene Summary: The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.

Gene is located in Chromosome: 20

Location in Chromosome : 20q11.21

Description of this Gene: HCK proto-oncogene, Src family tyrosine kinase

Type of Gene: protein-coding

rs6058523 in HCK gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs1987960 in HCK gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs6089170 in HCK gene and Serum albumin measurement PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.