Gene: HDAC3

Alternate names for this Gene: HD3|KDAC3|RPD3|RPD3-2

Gene Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Gene is located in Chromosome: 5

Location in Chromosome : 5q31.3

Description of this Gene: histone deacetylase 3

Type of Gene: protein-coding

rs1554216308 in HDAC3 gene and Movement Disorders PMID 18830415 2008 Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice.

PMID 17416969 2007 Distribution of histone deacetylases 1-11 in the rat brain.

PMID 17158926 2007 Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2.

PMID 25800122 2015 HDAC8-deficiency causes an X-linked dominant disorder with a wide range of severity.

PMID 19109904 2008 Decoding the epigenetic language of neuronal plasticity.

PMID 25425123 2015 A new syndrome of intellectual disability with dysmorphism due to TBL1XR1 deletion.

PMID 10491319 1999 Cloning and characterization of the murine histone deacetylase (HDAC3).

PMID 23770587 2013 Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR.

PMID 11742974 2001 Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.

PMID 10860984 2000 The histone deacetylase-3 complex contains nuclear receptor corepressors.

PMID 10944117 2000 Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3.

PMID 15837933 2005 Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors.

PMID 10748092 2000 N-terminal region, C-terminal region, nuclear export signal, and deacetylation activity of histone deacetylase-3 are essential for the viability of the DT40 chicken B cell line.

PMID 11509652 2001 The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3.

PMID 15897262 2005 Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain.

PMID 25209348 2015 Cornelia de Lange syndrome.

PMID 22230954 2012 Structure of HDAC3 bound to co-repressor and inositol tetraphosphate.

PMID 21545841 2011 Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity.

PMID 27543892 2016 A recurrent mutation in KCNA2 as a novel cause of hereditary spastic paraplegia and ataxia.

PMID 25339172 2014 Histone deacetylase 3 is necessary for proper brain development.

PMID 22363205 2012 Histone deacetylase complexes promote trinucleotide repeat expansions.

PMID 26795593 2016 Diagnostic exome sequencing provides a molecular diagnosis for a significant proportion of patients with epilepsy.

PMID 25102098 2014 A girl with West syndrome and autistic features harboring a de novo TBL1XR1 mutation.

PMID 22495309 2012 Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.

PMID 20691407 2010 Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems.