Gene: HGS

Alternate names for this Gene: HRS

Gene Summary: The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.

Gene is located in Chromosome: 17

Location in Chromosome : 17q25.3

Description of this Gene: hepatocyte growth factor-regulated tyrosine kinase substrate

Type of Gene: protein-coding

Gene: ARL16

Alternate names for this Gene: -

Gene Summary: The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). This protein has been shown to have an inhibitory role in the cellular antiviral response. This gene product interacts with the C-terminal domain of the DEXD/H-box helicase 58 (DDX58) gene product. This interaction was found to suppress the association between the DDX58 gene product and RNA, thereby negatively regulating the activity of the DDX58 gene product.

Gene is located in Chromosome: 17

Location in Chromosome : 17q25.3

Description of this Gene: ADP ribosylation factor like GTPase 16

Type of Gene: protein-coding