Gene: HLA-F-AS1

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.1

Description of this Gene: HLA-F antisense RNA 1

Type of Gene: ncRNA

Gene: HLA-F

Alternate names for this Gene: CDA12|HLA-5.4|HLA-CDA12|HLAF

Gene Summary: This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.1

Description of this Gene: major histocompatibility complex, class I, F

Type of Gene: protein-coding

rs1610601 in HLA-F-AS1;HLA-F gene and Arthritis, Psoriatic PMID 30552173 2019 Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis.

rs1633096 in HLA-F-AS1;HLA-F gene and Mixed Cellularity Hodgkin Lymphoma PMID 29196614 2017 Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1).

rs1059174 in HLA-F-AS1;HLA-F gene and Multiple Sclerosis PMID 17660530 2007 Risk alleles for multiple sclerosis identified by a genomewide study.

rs2523405 in HLA-F-AS1;HLA-F gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.