Gene: HLA-J

Alternate names for this Gene: CDA12|D6S203|HLA-59|HLA-CDA12

Gene Summary: This major histocompatibility complex gene represents a transcribed pseudogene, possibly derived from HLA-A.

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.1

Description of this Gene: major histocompatibility complex, class I, J (pseudogene)

Type of Gene: pseudo

Gene: ZNRD1ASP

Alternate names for this Gene: C6orf12|HCG8|HCGVIII|HCGVIII-1|HTEX4|NCRNA00171|TCTEX4|ZNRD1-AS|ZNRD1-AS1|ZNRD1AS|ZNRD1AS1

Gene Summary:

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.1

Description of this Gene: zinc ribbon domain containing 1 antisense, pseudogene

Type of Gene: pseudo

Gene: HLA-A

Alternate names for this Gene: HLAA

Gene Summary: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen so that they can be recognized by cytotoxic T cells. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions.

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.1

Description of this Gene: major histocompatibility complex, class I, A

Type of Gene: protein-coding

rs4313034 in HLA-J;ZNRD1ASP;HLA-A gene and Corpuscular Hemoglobin Concentration Mean PMID 23222517 2012 Seventy-five genetic loci influencing the human red blood cell.

rs4313034 in HLA-J;ZNRD1ASP;HLA-A gene and Graves Disease PMID 21900946 2011 Multivariate stepwise logistic regression analysis selected rs3893464, rs4313034, rs3132613, rs4248154, rs2273017, rs9394159 and rs4713693, as markers for independent risk loci for GD.

rs4313034 in HLA-J;ZNRD1ASP;HLA-A gene and Oral Ulcer PMID 30837455 2019 Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.