Gene: HOOK2
Alternate names for this Gene: HK2
Gene Summary: Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004].
Gene is located in Chromosome: 19
Location in Chromosome : 19p13.13
Description of this Gene: hook microtubule tethering protein 2
Type of Gene: protein-coding
Gene: RNASEH2A
Alternate names for this Gene: AGS4|JUNB|RNASEHI|RNHIA|RNHL|THSD8
Gene Summary: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.
Gene is located in Chromosome: 19
Location in Chromosome : 19p13.13
Description of this Gene: ribonuclease H2 subunit A
Type of Gene: protein-coding