Gene: HOXB13

Alternate names for this Gene: HPC9|PSGD

Gene Summary: This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region.

Gene is located in Chromosome: 17

Location in Chromosome : 17q21.32

Description of this Gene: homeobox B13

Type of Gene: protein-coding

rs138213197 in HOXB13 gene and Neoplastic Syndromes, Hereditary PMID 23064873 2013 HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG).

PMID 23292082 2013 HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk.

PMID 23393222 2013 The G84E mutation of HOXB13 is associated with increased risk for prostate cancer: results from the REDUCE trial.

PMID 23457453 2013 Population-based estimate of prostate cancer risk for carriers of the HOXB13 missense mutation G84E.

PMID 22781434 2012 Association between germline HOXB13 G84E mutation and risk of prostate cancer.

PMID 23518396 2013 Germline homeobox B13 (HOXB13) G84E mutation and prostate cancer risk in European descendants: a meta-analysis of 24,213 cases and 73, 631 controls.

PMID 22841674 2014 A population-based assessment of germline HOXB13 G84E mutation and prostate cancer risk.

PMID 24310616 2014 Prevalence of the HOXB13 G84E mutation among unaffected men with a family history of prostate cancer.

PMID 25629170 2015 Imputation of the rare HOXB13 G84E mutation and cancer risk in a large population-based cohort.

PMID 15964834 2005 Hoxb13 up-regulates transglutaminase activity and drives terminal differentiation in an epidermal organotypic model.

PMID 25206306 2014 Dysregulation of the homeobox transcription factor gene HOXB13: role in prostate cancer.

PMID 22853031 2012 Association of a HOXB13 variant with breast cancer.

PMID 22714738 2012 Confirmation of the HOXB13 G84E germline mutation in familial prostate cancer.

PMID 28798948 2017 HOXB13 mutations and binding partners in prostate development and cancer: Function, clinical significance, and future directions.

PMID 26517352 2015 Germline HOXB13 p.Gly84Glu mutation and cancer susceptibility: a pooled analysis of 25 epidemiological studies with 145,257 participates.

PMID 26779768 2016 Prevalence of the HOXB13 G84E mutation in Danish men undergoing radical prostatectomy and its correlations with prostate cancer risk and aggressiveness.

PMID 28050579 2016 Oncogenic mechanisms of HOXB13 missense mutations in prostate carcinogenesis.

PMID 17138648 2007 Posterior Hox gene expression and differential androgen regulation in the developing and adult rat prostate lobes.

PMID 26108461 2015 The HOXB13 G84E Mutation Is Associated with an Increased Risk for Prostate Cancer and Other Malignancies.

PMID 8756292 1996 Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity.

PMID 27153395 2016 Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer.

PMID 27902461 2017 Whole exome sequencing in 75 high-risk families with validation and replication in independent case-control studies identifies TANGO2, OR5H14, and CHAD as new prostate cancer susceptibility genes.

PMID 23541221 2013 Germline HOXB13 p.Gly84Glu mutation and risk of colorectal cancer.

PMID 27424772 2016 Recurrent HOXB13 mutations in the Dutch population do not associate with increased breast cancer risk.

PMID 22236224 2012 Germline mutations in HOXB13 and prostate-cancer risk.

PMID 24026887 2014 G84E mutation in HOXB13 is firmly associated with prostate cancer risk: a meta-analysis.

rs138213197 in HOXB13 gene and Prostate carcinoma PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.