Gene: HPN-AS1

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: HPN

Alternate names for this Gene: TMPRSS1

Gene Summary: This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 19

Location in Chromosome : 19q13.11

Description of this Gene: hepsin

Type of Gene: protein-coding

rs10406943 in HPN-AS1;HPN gene and Blood Protein Measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs1688043 in HPN-AS1;HPN gene and C-reactive protein measurement PMID 27286809 2016 Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

rs149131600 in HPN-AS1;HPN gene and Diabetes PMID 31511532 2019 Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

rs149131600 in HPN-AS1;HPN gene and Diabetes Mellitus PMID 31511532 2019 Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

rs4806073 in HPN-AS1;HPN gene and Serum albumin level PMID 23022100 2012 Discovery and fine mapping of serum protein loci through transethnic meta-analysis.

rs1688043 in HPN-AS1;HPN gene and Serum albumin measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

PMID 23022100 2012 Discovery and fine mapping of serum protein loci through transethnic meta-analysis.

rs1688043 in HPN-AS1;HPN gene and Triglycerides measurement PMID 27286809 2016 Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.