Gene: HSD17B6

Alternate names for this Gene: HSE|RODH|SDR9C6

Gene Summary: The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family.

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.3

Description of this Gene: hydroxysteroid 17-beta dehydrogenase 6

Type of Gene: protein-coding

rs2958137 in HSD17B6 gene and Platelet Count measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs2958137 in HSD17B6 gene and Red Blood Cell Count measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.