Gene: HSH2D

Alternate names for this Gene: ALX|HSH2

Gene Summary: T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008].

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.11

Description of this Gene: hematopoietic SH2 domain containing

Type of Gene: protein-coding

rs681059 in HSH2D gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs16981122 in HSH2D gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.