Gene: HTRA1

Alternate names for this Gene: ARMD7|CADASIL2|CARASIL|HtrA|L56|ORF480|PRSS11

Gene Summary: This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.

Gene is located in Chromosome: 10

Location in Chromosome : 10q26.13

Description of this Gene: HtrA serine peptidase 1

Type of Gene: protein-coding

Gene: LOC105378525

Alternate names for this Gene:

Gene Summary:

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Description of this Gene:

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rs3793917 in HTRA1;LOC105378525 gene and Age related macular degeneration PMID 23326517 2013 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.

PMID 20385819 2010 Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.