Gene: IBSP

Alternate names for this Gene: BNSP|BSP|BSP-II|SP-II

Gene Summary: The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.

Gene is located in Chromosome: 4

Location in Chromosome : 4q22.1

Description of this Gene: integrin binding sialoprotein

Type of Gene: protein-coding

rs1054627 in IBSP gene and Bone Density PMID 21533022 2011 Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.

rs1054627 in IBSP gene and Bone Mineral Density Test PMID 21533022 2011 Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.