Gene: IER3

Alternate names for this Gene: DIF-2|DIF2|GLY96|IEX-1|IEX-1L|IEX1|PRG1

Gene Summary: This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: immediate early response 3

Type of Gene: protein-coding

rs2284174 in IER3 gene and Chronic Obstructive Airway Disease PMID 30804561 2019 Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.

rs2284174 in IER3 gene and Major Depressive Disorder PMID 29662059 2018 Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.

rs3130662 in IER3 gene and Sarcoidosis PMID 26651848 2016 High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences.