Gene: IFI30

Alternate names for this Gene: GILT|IFI-30|IP-30|IP30

Gene Summary: The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.11

Description of this Gene: IFI30 lysosomal thiol reductase

Type of Gene: protein-coding

rs11554159 in IFI30 gene and Multiple Sclerosis PMID 24076602 2013 Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.