Gene: IFNL3

Alternate names for this Gene: IFN-lambda-3|IFN-lambda-4|IL-28B|IL-28C|IL28B|IL28C

Gene Summary: This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).

Gene is located in Chromosome: 19

Location in Chromosome : 19q13.2

Description of this Gene: interferon lambda 3

Type of Gene: protein-coding

rs28416813 in IFNL3 gene and Hepatitis C, Chronic PMID 19749757 2009 Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.