Gene: IGF2

Alternate names for this Gene: C11orf43|GRDF|IGF-II|PP9974|SRS3

Gene Summary: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: insulin like growth factor 2

Type of Gene: protein-coding

Gene: INS-IGF2

Alternate names for this Gene: INSIGF

Gene Summary: This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: INS-IGF2 readthrough

Type of Gene: protein-coding

Gene: IGF2-AS

Alternate names for this Gene: IGF2-AS1|IGF2AS|PEG8

Gene Summary: This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: IGF2 antisense RNA

Type of Gene: ncRNA

rs1004446 in IGF2;INS-IGF2;IGF2-AS gene and Autoantibody measurement PMID 21829393 2011 Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

rs35506085 in IGF2;INS-IGF2;IGF2-AS gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1004446 in IGF2;INS-IGF2;IGF2-AS gene and Diabetes Mellitus, Insulin-Dependent PMID 17632545 2007 A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.

PMID 21829393 2011 Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

rs35506085 in IGF2;INS-IGF2;IGF2-AS gene and Lean body mass PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.

rs1004446 in IGF2;INS-IGF2;IGF2-AS gene and Multiple Sclerosis PMID 22190364 2011 Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

rs35506085 in IGF2;INS-IGF2;IGF2-AS gene and Uric acid measurement (procedure) PMID 31578528 2019 Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.