Gene: IGF2BP1

Alternate names for this Gene: CRD-BP|CRDBP|IMP-1|IMP1|VICKZ1|ZBP1

Gene Summary: This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 17

Location in Chromosome : 17q21.32

Description of this Gene: insulin like growth factor 2 mRNA binding protein 1

Type of Gene: protein-coding

rs11079849 in IGF2BP1 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs4643373 in IGF2BP1 gene and Coronary Artery Disease PMID 28714975 2017 Association analyses based on false discovery rate implicate new loci for coronary artery disease.

rs11079849 in IGF2BP1 gene and Intelligence PMID 29942086 2018 Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.

rs9906944 in IGF2BP1 gene and body fat percentage (physical finding) PMID 26833246 2016 New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.