Gene: IL10

Alternate names for this Gene: CSIF|GVHDS|IL-10|IL10A|TGIF

Gene Summary: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Gene is located in Chromosome: 1

Location in Chromosome : 1q32.1

Description of this Gene: interleukin 10

Type of Gene: protein-coding

Gene: IL19

Alternate names for this Gene: IL-10C|MDA1|NG.1|ZMDA1

Gene Summary: The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.

Gene is located in Chromosome: 1

Location in Chromosome : 1q32.1

Description of this Gene: interleukin 19

Type of Gene: protein-coding