Gene: IL18

Alternate names for this Gene: IGIF|IL-18|IL-1g|IL1F4

Gene Summary: The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11q23.1

Description of this Gene: interleukin 18

Type of Gene: protein-coding

rs1834481 in IL18 gene and C-reactive protein measurement PMID 24182552 2014 Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.

rs1834481 in IL18 gene and Interleukin 18 Measurement PMID 20150558 2010 Forward selection analysis indicated that SNPs rs2115763 and rs1834481 were independently associated with IL-18 levels (P=0.0002 and 0.0006, respectively).