Gene: IL6-AS1

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 7

Location in Chromosome : 7p15.3

Description of this Gene: IL6 antisense RNA 1

Type of Gene: ncRNA

Gene: IL6

Alternate names for this Gene: BSF-2|BSF2|CDF|HGF|HSF|IFN-beta-2|IFNB2|IL-6

Gene Summary: This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 7

Location in Chromosome : 7p15.3

Description of this Gene: interleukin 6

Type of Gene: protein-coding

rs1474348 in IL6-AS1;IL6 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2069837 in IL6-AS1;IL6 gene and Longevity PMID 26912274 2016 Novel loci and pathways significantly associated with longevity.

PMID 31413261 2019 A meta-analysis of genome-wide association studies identifies multiple longevity genes.

rs2069837 in IL6-AS1;IL6 gene and Takayasu Arteritis PMID 25604533 2015 We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).