Gene: INSL3

Alternate names for this Gene: RLF|RLNL|ley-I-L

Gene Summary: This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.11

Description of this Gene: insulin like 3

Type of Gene: protein-coding

rs104894697 in INSL3 gene and Cryptorchidism PMID 12601553 2003 A novel mutation of the insulin-like 3 gene in patients with cryptorchidism.

PMID 11095425 2000 Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism.

PMID 11746019 2001 Novel insulin-like 3 (INSL3) gene mutation associated with human cryptorchidism.