Gene: IQSEC1

Alternate names for this Gene: ARF-GEP100|ARFGEP100|BRAG2|GEP100|IDDSSBA

Gene Summary:

Gene is located in Chromosome: 3

Location in Chromosome : 3p25.2-p25.1

Description of this Gene: IQ motif and Sec7 domain ArfGEF 1

Type of Gene: protein-coding

rs9864101 in IQSEC1 gene and Intracranial Aneurysm PMID 20613766 2010 Consequently, five SNPs (P=1.31 × 10(-5) for rs1930095 of intergenic region; P=1.32 × 10(-5) for rs4628172 of TMEM195; P=2.78 × 10(-5) for rs7781293 of TMEM195; P=4.93 × 10(-5) for rs7550260 of ARHGEF11; and P=3.63 × 10(-5) for rs9864101 of IQSEC1) with probabilities of being false positives <0.5 were associated with IA in Japanese population, and the susceptibility genes could have a role in actin remodeling in the ELN/LIMK pathway.

rs361052 in IQSEC1 gene and Pancreatic carcinoma PMID 28470677 2017 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study.

rs428862 in IQSEC1 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.