Gene: IQSEC2
Alternate names for this Gene: BRAG1|IQ-ArfGEF|MRX1|MRX18|MRX78
Gene Summary: This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene is located in Chromosome: X
Location in Chromosome : Xp11.22
Description of this Gene: IQ motif and Sec7 domain ArfGEF 2
Type of Gene: protein-coding