Gene: IRS1

Alternate names for this Gene: HIRS-1

Gene Summary: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Gene is located in Chromosome: 2

Location in Chromosome : 2q36.3

Description of this Gene: insulin receptor substrate 1

Type of Gene: protein-coding

rs2229613 in IRS1 gene and Low density lipoprotein cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs2229613 in IRS1 gene and Serum LDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs2229613 in IRS1 gene and Serum total cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs142101835 in IRS1 gene and body fat percentage (physical finding) PMID 28270201 2017 Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.