Gene: KLF2

Alternate names for this Gene: LKLF

Gene Summary: This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.11

Description of this Gene: Kruppel like factor 2

Type of Gene: protein-coding

rs3745318 in KLF2 gene and Diastolic blood pressure PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

rs11086029 in KLF2 gene and Multiple Myeloma PMID 30213928 2018 Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.