Gene: KLRG1

Alternate names for this Gene: 2F1|CLEC15A|MAFA|MAFA-2F1|MAFA-L|MAFA-LIKE

Gene Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules.

Gene is located in Chromosome: 12

Location in Chromosome : 12p13.31

Description of this Gene: killer cell lectin like receptor G1

Type of Gene: protein-coding

rs11048434 in KLRG1 gene and Sjogren's Syndrome PMID 28076899 2017 Genome-Wide Association Analysis Reveals Genetic Heterogeneity of Sjögren's Syndrome According to Ancestry.