Gene: KMT2E

Alternate names for this Gene: HDCMC04P|MLL5|NKp44L|ODLURO

Gene Summary: This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized.

Gene is located in Chromosome: 7

Location in Chromosome : 7q22.3

Description of this Gene: lysine methyltransferase 2E (inactive)

Type of Gene: protein-coding

rs111931861 in KMT2E gene and Child Development Disorders, Pervasive PMID 30804558 2019 Identification of common genetic risk variants for autism spectrum disorder.

rs9655780 in KMT2E gene and Intelligence PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.