Gene: KPNA3

Alternate names for this Gene: IPOA4|SRP1|SRP1gamma|SRP4|hSRP1

Gene Summary: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import.

Gene is located in Chromosome: 13

Location in Chromosome : 13q14.2

Description of this Gene: karyopherin subunit alpha 3

Type of Gene: protein-coding

rs3736830 in KPNA3 gene and Age at menopause PMID 22267201 2012 Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.