Gene: KREMEN1
Alternate names for this Gene: ECTD13|KREMEN|KRM1
Gene Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
Gene is located in Chromosome: 22
Location in Chromosome : 22q12.1
Description of this Gene: kringle containing transmembrane protein 1
Type of Gene: protein-coding