Gene: KYNU

Alternate names for this Gene: KYNUU|VCRL2

Gene Summary: Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 2

Location in Chromosome : 2q22.2

Description of this Gene: kynureninase

Type of Gene: protein-coding

rs1135401744 in KYNU gene and 11 pairs of ribs PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs1135401744 in KYNU gene and 2-3 toe syndactyly PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs1135401744 in KYNU gene and Anteriorly placed anus PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs3768844 in KYNU gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

PMID 29875488 2018 Genomic atlas of the human plasma proteome.

PMID 31320639 2019 Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936.

rs1135401744 in KYNU gene and Congenital clubfoot PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs1135401744 in KYNU gene and Congenital hypoplasia of kidney PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs1135401744 in KYNU gene and Defect of vertebral segmentation PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs758865880 in KYNU gene and Delayed speech and language development PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs758865880 in KYNU gene and Frontal bossing PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs606231307 in KYNU gene and Hydroxykynureninuria PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

PMID 17334708 2007 Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase.

rs758865880 in KYNU gene and Hypoplastic Left Heart Syndrome PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs758865880 in KYNU gene and Hypothyroidism PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs1135401744 in KYNU gene and Low set ears PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs1135401744 in KYNU gene and Mild microcephaly PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs1135401744 in KYNU gene and Patent ductus arteriosus PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs1135401744 in KYNU gene and Short long bone PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs1135401744 in KYNU gene and Short neck PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs1135401744 in KYNU gene and Thoracic hemivertebra PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs758865880 in KYNU gene and Unilateral agenesis of kidney PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

rs1135401744 in KYNU gene and Upward slant of palpebral fissure PMID 28792876 2017 NAD Deficiency, Congenital Malformations, and Niacin Supplementation.