Gene: LGR6

Alternate names for this Gene: GPCR|VTS20631

Gene Summary: This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.

Gene is located in Chromosome: 1

Location in Chromosome : 1q32.1

Description of this Gene: leucine rich repeat containing G protein-coupled receptor 6

Type of Gene: protein-coding

rs17489300 in LGR6 gene and Breast Carcinoma PMID 27117709 2016 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.

PMID 23535733 2013 Genome-wide association studies identify four ER negative-specific breast cancer risk loci.

rs6678914 in LGR6 gene and Malignant neoplasm of breast PMID 23535733 2013 Genome-wide association studies identify four ER negative-specific breast cancer risk loci.