Gene: LHX2
Alternate names for this Gene: LH2|hLhx2
Gene Summary: This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.
Gene is located in Chromosome: 9
Location in Chromosome : 9q33.3
Description of this Gene: LIM homeobox 2
Type of Gene: protein-coding
rs917783 in
LHX2 gene and
Hair Color
PMID 30531825 2018 Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.
rs58649573 in
LHX2 gene and
Post-Traumatic Stress Disorder
PMID 25456346 2015 Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.
rs2075064 in
LHX2 gene and
Waist Circumference
PMID 23966867 2013 In joint analysis of association results including both Stage 1 and 2 cohorts, 2 SNPs demonstrated association, rs2075064 at LHX2, p = 2.24×10(-8) for WC-adjusted-for-BMI, and rs6931262 at RREB1, p = 2.48×10(-8) for WHR-adjusted-for-BMI.