Gene: LIMS1

Alternate names for this Gene: PINCH|PINCH-1|PINCH1

Gene Summary: The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 2

Location in Chromosome : 2q12.3

Description of this Gene: LIM zinc finger domain containing 1

Type of Gene: protein-coding

rs6542772 in LIMS1 gene and Hirsutism PMID 29895819 2018 Excessive hairiness signals' top SNPs were also eQTLs for TBX15 (rs984225; P = 1.6 × 10<sup>-8</sup>), BCL2 (rs7226979; P = 7.3 × 10<sup>-11</sup>), and GCC2 and LIMS1 (rs6542772; P = 2.2 × 10<sup>-9</sup>).

rs826681 in LIMS1 gene and Low density lipoprotein cholesterol measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs826681 in LIMS1 gene and Serum total cholesterol measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.