Gene: LIN28B

Alternate names for this Gene: CSDD2

Gene Summary: The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

Gene is located in Chromosome: 6

Location in Chromosome : 6q16.3-q21

Description of this Gene: lin-28 homolog B

Type of Gene: protein-coding

Gene: LIN28B-AS1

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

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Description of this Gene:

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rs2095812 in LIN28B;LIN28B-AS1 gene and Age at menarche PMID 19448620 2009 Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.

rs1475120 in LIN28B;LIN28B-AS1 gene and Major Depressive Disorder PMID 27479909 2016 Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.