Gene: LINC00461

Alternate names for this Gene: ECONEXIN|EyeLinc1|NDIME|VISC

Gene Summary: This is an evolutionarily conserved gene that produces alternatively spliced long non-coding RNAs that may be expressed predominantly in the brain and visual cortex. These transcripts may be involved in tumorigenesis, as depletion by siRNA suppressed glioma cell division. Transcripts may also bind to and regulate the activity of miR-411-5p and argonaut 2, thereby altering the expression of genes involved in tumor growth.

Gene is located in Chromosome: 5

Location in Chromosome : 5q14.3

Description of this Gene: long intergenic non-protein coding RNA 461

Type of Gene: ncRNA

Gene: MIR9-2

Alternate names for this Gene: MIRN9-2|hsa-mir-9-2|miRNA9-2|mir-9-2

Gene Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Gene is located in Chromosome: 5

Location in Chromosome : 5q14.3

Description of this Gene: microRNA 9-2

Type of Gene: ncRNA