Gene: LINC00673

Alternate names for this Gene: ERRLR01|HI-LNC75|HILNC75|LUCAIR1|SLNCR|SLNCR1

Gene Summary: This gene produces a long non-protein coding RNA that is involved in the regulation of gene expression during tumor progression. This transcript can promote cell proliferation in gastric cancer through interaction with enhancer of zeste 2 and other epigenetic suppressors of gene expression, thereby downregulating target genes including Kruppel like factors 2 and 4. This transcript may also act as a tumor suppressor by promoting interaction between protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) and ubiquitin ligase, resulting in degradation of Ptpn11 and lowered oncogenic signalling. Naturally-occurring variation at this locus results in the formation of a binding site for miR-1231, which negatively regulates activity of this transcript. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 17

Location in Chromosome : 17q24.3

Description of this Gene: long intergenic non-protein coding RNA 673

Type of Gene: ncRNA

Gene: LINC00511

Alternate names for this Gene:

Gene Summary:

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rs11652463 in LINC00673;LINC00511 gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs7214041 in LINC00673;LINC00511 gene and Pancreatic carcinoma PMID 29422604 2018 Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

rs56868433 in LINC00673;LINC00511 gene and Serum albumin measurement PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.