Gene: LMTK2

Alternate names for this Gene: AATYK2|BREK|KPI-2|KPI2|LMR2|PPP1R100|cprk|hBREK

Gene Summary: The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.

Gene is located in Chromosome: 7

Location in Chromosome : 7q21.3

Description of this Gene: lemur tyrosine kinase 2

Type of Gene: protein-coding

rs6465654 in LMTK2 gene and Malignant neoplasm of prostate PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.

PMID 19767753 2009 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.

rs6465657 in LMTK2 gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

rs6465657 in LMTK2 gene and Prostate carcinoma PMID 19767753 2009 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.

PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.

rs1495525 in LMTK2 gene and Serum gamma-glutamyl transferase measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.