Gene: LOC101929710

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: CAST

Alternate names for this Gene: BS-17|PLACK

Gene Summary: The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene is located in Chromosome: 5

Location in Chromosome : 5q15

Description of this Gene: calpastatin

Type of Gene: protein-coding

rs10062657 in LOC101929710;CAST gene and Body mass index PMID 28892062 2017 Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs11951673 in LOC101929710;CAST gene and Body mass index procedure PMID 22344219 2012 Meta-analysis identifies common variants associated with body mass index in east Asians.

rs11951673 in LOC101929710;CAST gene and Finding of body mass index PMID 22344219 2012 Meta-analysis identifies common variants associated with body mass index in east Asians.