Gene: LOC105369781

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: IKZF4

Alternate names for this Gene: EOS|ZNFN1A4

Gene Summary: Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK314543.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END##

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.2

Description of this Gene: IKAROS family zinc finger 4

Type of Gene: protein-coding

rs1701704 in LOC105369781;IKZF4 gene and Alopecia Areata PMID 20596022 2010 Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.

rs1701704 in LOC105369781;IKZF4 gene and Asthma PMID 21804548 2011 Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.

rs1701704 in LOC105369781;IKZF4 gene and Autoantibody measurement PMID 21829393 2011 Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

rs1701704 in LOC105369781;IKZF4 gene and Diabetes Mellitus, Insulin-Dependent PMID 21829393 2011 Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

PMID 18198356 2008 It involves type 1 diabetes association with the minor allele of rs1701704 (P = 9.13 x 10(-10), OR 1.25 [95% CI 1.12-1.40]).

rs1701704 in LOC105369781;IKZF4 gene and Vitiligo PMID 22561518 2012 Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.

PMID 27723757 2016 Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants.