Gene: LOC105370557

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: PCNX1

Alternate names for this Gene: PCNX|PCNXL1|pecanex

Gene Summary: This gene encodes an evolutionarily conserved transmembrane protein similar to the pecanex protein in Drosophila. The fly protein is a component of the Notch signaling pathway, which functions in several developmental processes.

Gene is located in Chromosome: 14

Location in Chromosome : 14q24.2

Description of this Gene: pecanex 1

Type of Gene: protein-coding

rs143046984 in LOC105370557;PCNX1 gene and Adenocarcinoma of large intestine PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.

rs143046984 in LOC105370557;PCNX1 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.

rs143046984 in LOC105370557;PCNX1 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.

rs143046984 in LOC105370557;PCNX1 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.

rs143046984 in LOC105370557;PCNX1 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.

rs143046984 in LOC105370557;PCNX1 gene and Colorectal Carcinoma PMID 27207650 2016 We discovered 17 variants across 4 independent regions that merit further investigation due to suggestive CRC associations (P < 1×10(-6)) at 1p34.3 (rs7528276; Odds Ratio (OR) = 1.86 [95% confidence interval (CI): 1.47-2.36); P = 2.5×10(-7)], 2q23.3 (rs1367374; OR = 1.37 (95% CI: 1.21-1.55); P = 4.0×10(-7)), 14q24.2 (rs143046984; OR = 1.65 (95% CI: 1.36-2.01); P = 4.1×10(-7)) and 16q12.2 [rs142319636; OR = 1.69 (95% CI: 1.37-2.08); P=7.8×10(-7)].

rs143046984 in LOC105370557;PCNX1 gene and Colorectal Neoplasms PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.

rs143046984 in LOC105370557;PCNX1 gene and Malignant neoplasm of large intestine PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.

rs143046984 in LOC105370557;PCNX1 gene and Malignant tumor of colon PMID 27207650 2016 Genome-wide association study of colorectal cancer in Hispanics.