Gene: LOC105370559

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: RGS6

Alternate names for this Gene: GAP|HA117|S914

Gene Summary: This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.

Gene is located in Chromosome: 14

Location in Chromosome : 14q24.2

Description of this Gene: regulator of G protein signaling 6

Type of Gene: protein-coding

rs17180489 in LOC105370559;RGS6 gene and RESTING HEART RATE PMID 29769521 2018 Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.

PMID 27798624 2016 Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.

rs17180489 in LOC105370559;RGS6 gene and heart rate PMID 28610988 2017 Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts.