Gene: LOC105370913

Alternate names for this Gene:

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Gene is located in Chromosome:

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Description of this Gene:

Type of Gene:

Gene: LOC112268142

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Gene Summary:

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Description of this Gene:

Type of Gene:

Gene: CHRNB4

Alternate names for this Gene: -

Gene Summary: This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene is located in Chromosome: 15

Location in Chromosome : 15q25.1

Description of this Gene: cholinergic receptor nicotinic beta 4 subunit

Type of Gene: protein-coding

rs12324870 in LOC105370913;LOC112268142;CHRNB4 gene and Forced expiratory volume function PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.