Gene: LOC105376536

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: LMO1

Alternate names for this Gene: RBTN1|RHOM1|TTG1

Gene Summary: This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.4

Description of this Gene: LIM domain only 1

Type of Gene: protein-coding

rs110419 in LOC105376536;LMO1 gene and Body Height PMID 29782485 2018 Evaluation and application of summary statistic imputation to discover new height-associated loci.

PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.

rs110419 in LOC105376536;LMO1 gene and Diastolic blood pressure PMID 27618447 2016 Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

rs110419 in LOC105376536;LMO1 gene and Neuroblastoma PMID 21124317 2011 Integrative genomics identifies LMO1 as a neuroblastoma oncogene.

PMID 22941191 2012 Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.