Gene: LOC105378519

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: WDR11

Alternate names for this Gene: BRWD2|DR11|HH14|SRI1|WDR15

Gene Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.

Gene is located in Chromosome: 10

Location in Chromosome : 10q26.12

Description of this Gene: WD repeat domain 11

Type of Gene: protein-coding

rs139007744 in LOC105378519;WDR11 gene and HYPOGONADOTROPIC HYPOGONADISM 14 WITH OR WITHOUT ANOSMIA PMID 20887964 2010 WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.

PMID 29263200 2018 WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.