Gene: LOC107986462

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: HTR4

Alternate names for this Gene: 5-HT4|5-HT4R

Gene Summary: This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.

Gene is located in Chromosome: 5

Location in Chromosome : 5q32

Description of this Gene: 5-hydroxytryptamine receptor 4

Type of Gene: protein-coding

rs12374521 in LOC107986462;HTR4 gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10037493 in LOC107986462;HTR4 gene and Chronic Obstructive Airway Disease PMID 30804561 2019 Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.

rs11168048 in LOC107986462;HTR4 gene and Forced expiratory volume function PMID 23284291 2012 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.

PMID 26423011 2015 Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.

PMID 20010834 2010 Genome-wide association study identifies five loci associated with lung function.

PMID 28166213 2017 Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

rs10463406 in LOC107986462;HTR4 gene and Pulmonary function PMID 20010835 2010 Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

PMID 20010834 2010 Genome-wide association study identifies five loci associated with lung function.

rs10463406 in LOC107986462;HTR4 gene and Pulmonary function (finding) PMID 20010835 2010 Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

PMID 20010834 2010 Genome-wide association study identifies five loci associated with lung function.

rs11168048 in LOC107986462;HTR4 gene and Respiratory Function Tests PMID 20010835 2010 Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

PMID 23284291 2012 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.

PMID 20010834 2010 Genome-wide association study identifies five loci associated with lung function.