Gene: LOC389641

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: TNFRSF10A

Alternate names for this Gene: APO2|CD261|DR4|TRAILR-1|TRAILR1

Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.

Gene is located in Chromosome: 8

Location in Chromosome : 8p21.3

Description of this Gene: TNF receptor superfamily member 10a

Type of Gene: protein-coding

rs13278062 in LOC389641;TNFRSF10A gene and Age related macular degeneration PMID 21909106 2011 In addition to CFH (rs800292, P = 4.23 × 10(-15)) and ARMS2 (rs3750847, P = 8.67 × 10(-29)) loci, we identified two new susceptibility loci for exudative AMD: TNFRSF10A-LOC389641 on chromosome 8p21 (rs13278062, combined P = 1.03 × 10(-12), odds ratio = 0.73) and REST-C4orf14-POLR2B-IGFBP7 on chromosome 4q12 (rs1713985, combined P = 2.34 × 10(-8), odds ratio = 1.30).

PMID 23455636 2013 Seven new loci associated with age-related macular degeneration.