Gene: LOX
Alternate names for this Gene: AAT10
Gene Summary: This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections.
Gene is located in Chromosome: 5
Location in Chromosome : 5q23.1
Description of this Gene: lysyl oxidase
Type of Gene: protein-coding