Gene: LRRC3B

Alternate names for this Gene: LRP15

Gene Summary: The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene.

Gene is located in Chromosome: 3

Location in Chromosome : 3p24.1

Description of this Gene: leucine rich repeat containing 3B

Type of Gene: protein-coding

rs1599923 in LRRC3B gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.