Gene: LRRC71

Alternate names for this Gene: C1orf92

Gene Summary:

Gene is located in Chromosome: 1

Location in Chromosome : 1q23.1

Description of this Gene: leucine rich repeat containing 71

Type of Gene: protein-coding

Gene: ARHGEF11

Alternate names for this Gene: GTRAP48|PDZ-RHOGEF

Gene Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

Gene is located in Chromosome: 1

Location in Chromosome : 1q23.1

Description of this Gene: Rho guanine nucleotide exchange factor 11

Type of Gene: protein-coding

rs2275200 in LRRC71;ARHGEF11 gene and Intelligence PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.